Abstract We have identified two novel potent and selective inhibitors of inducible nitric oxide synthase, S-ethylisothiourea and 2-amino-5, 6-dihydro-6-methyl-4H-1, 3-thiazine. Ki values of 14.7 nM for S-ethylisothiourea and 4.2 nM for 2-amino-5, 6-dihydro-6-methyl-4H-1, 3- thiazine were obtained with partially purified preparations of inducible nitric oxide synthase. These compounds demonstrate about 1000-fold greater potency than prototypical ...
[Lim, Herman D.; Smits, Rogier A.; Bakker, Remko A.; Van Dam, Cindy M. E.; De Esch, Iwan J. P.; Leurs, Rob Journal of Medicinal Chemistry, 2006 , vol. 49, # 23 p. 6650 - 6651]
