It has been found that 1-alkyl-3-(1-naphthoyl) indoles are potent agonists for the cannabinoid brain receptor and the 1-propyl-2-methyl analogue shows selectivity for the peripheral (spleen) cannabinoid receptor. 1, 2 In the course of preparing a series of 3-(4- methoxy-1-naphthoyl)-indole derivatives designed to be selective agonists for the peripheral receptor, the reaction of 3-(4-methoxy-1-naphthoyl) indole (1) with a series of primary alkyl ...
