Short synthesis of polyoxygenated macrocyclic rings using acetal linkages. Application to the preparation of a new lipidic polyamine

ML Miramon, N Mignet, J Herscovici

文献索引：Miramon, Marie-Laure; Mignet, Nathalie; Herscovici, Jean Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6949 - 6952

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被引用次数: 18

摘要

Gene therapy is a rapidly evolving field of medicine, in which DNA is the therapeutic agent. 1 , 2 DNA delivery systems mainly consist of either viral or synthetic vectors, viral vectors being the most widely used. However, the use of viruses is restricted by several drawbacks, such as immunological responses, biological safety, and limitation in the gene size. Synthetic vectors 3 , 4 offer an alternative to viral transfection. Compared to modified viruses, the major ...