Short synthesis of polyoxygenated macrocyclic rings using acetal linkages. Application to the preparation of a new lipidic polyamine

ML Miramon, N Mignet, J Herscovici

Index: Miramon, Marie-Laure; Mignet, Nathalie; Herscovici, Jean Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6949 - 6952

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Citation Number: 18

Abstract

Gene therapy is a rapidly evolving field of medicine, in which DNA is the therapeutic agent. 1 , 2 DNA delivery systems mainly consist of either viral or synthetic vectors, viral vectors being the most widely used. However, the use of viruses is restricted by several drawbacks, such as immunological responses, biological safety, and limitation in the gene size. Synthetic vectors 3 , 4 offer an alternative to viral transfection. Compared to modified viruses, the major ...