Biological activities of α-mangostin derivatives against acidic sphingomyelinase

…, Y Ishikawa, A Ikeda, K Umezawa, S Nishiyama

文献索引：Hamada, Motoko; Iikubo, Kazuhiko; Ishikawa, Yuichi; Ikeda, Aya; Umezawa, Kazuo; Nishiyama, Shigeru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 19 p. 3151 - 3153

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被引用次数: 36

摘要

Deprenyl and benzofenone-type congeners of α-mangostin 1 have been synthesized to understand their role for the inhibitory activity against sphingomyelinase (SMase). While removal of the prenyl group of the right side (11 and 12) caused loss of the selectivity between ASMase (acidic sphingomyelinase) and NSMase (neutral sphingomyelinase), the prenyl group of the left side appeared to increase the inhibitory activities (16 and 17).