Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties

D Shi, J Li, B Jiang, S Guo, H Su, T Wang

文献索引：Shi, Dayong; Li, Jing; Jiang, Bo; Guo, Shuju; Su, Hua; Wang, Tao Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2827 - 2832

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被引用次数: 19

摘要

A series of bromophenol derivatives were synthesized and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors in vitro and in vivo based on bromophenol 4e (IC50= 2.42 μmol/L), which was isolated from red algae Rhodomela confervoides. The results showed that all of the synthesized compounds displayed weak to good PTP1B inhibition at tested concentration. Among them, highly brominated compound 4g exhibited promising ...