Letters in Organic Chemistry

Direct Functionalization of Benzoquinolines

V Mamane, F Louerat, Y Fort

文献索引：Mamane, Victor; Louerat, Frederic; Fort, Yves Letters in Organic Chemistry, 2010 , vol. 7, # 1 p. 90 - 93

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被引用次数: 2

摘要

The first direct lithiation of the pyridine ring of benzo [h]-and benzo [f]-quinolines is reported. The method allowed the introduction of different electrophiles (Cl, Br and SPh) in 2-position. Other groups were introduced by direct nucleophilic addition of alkyllithiums allowing further transformations to functional groups such as esters and thiolesters.