The Journal of organic chemistry

Synthesis of optically active vicinal fluorohydrins by lipase-catalyzed deracemization

D Wölker, G Haufe

文献索引：Pietz, Sylke; Woelker, Doerthe; Haufe, Guenter Tetrahedron, 1997 , vol. 53, # 50 p. 17067 - 17078

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被引用次数: 21

摘要

Three microbial lipases have been used to deracemize trans-2-fluorocycloalkanols 2 both by hydrolysis of the corresponding acetates 3 or chloroacetates 4 and by esterification of the fluorohydrins 2 using vinyl acetate and vinyl chloroacetate, respectively. Pseudomonas