Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 β-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides

A Maresca, F Carta, D Vullo, A Scozzafava…

文献索引：Maresca, Alfonso; Carta, Fabrizio; Vullo, Daniela; Scozzafava, Andrea; Supuran, Claudiu T. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 4929 - 4932

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被引用次数: 16

摘要

A series of diazenylbenzenesulfonamides obtained from sulfanilamide or metanilamide by diazotization followed by coupling with phenols or amines, was tested for the inhibition of the β-carbonic anhydrases (CAs, EC 4.2. 1.1) encoded by the genes Rv1284 and Rv3273 of Mycobacterium tuberculosis. Several low micromolar inhibitors of the two enzymes were detected, with prontosil being the best inhibitor (KIs of 126–148nM). Inhibition of ...