Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic …

…, A Maresca, A Scozzafava, D Vullo, CT Supuran

文献索引：Carta, Fabrizio; Maresca, Alfonso; Scozzafava, Andrea; Vullo, Daniela; Supuran, Claudiu T. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 20 p. 7093 - 7099

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被引用次数: 15

摘要

A series of diazenylbenzenesulfonamides, azo-dye derivatives of sulfanilamide or metanilamide incorporating phenol and amine moieties, were tested for inhibition of the tumor-associated isozymes of carbonic anhydrase (CA, EC 4.2. 1.1), CA IX and XII. These compounds showed moderate-low inhibitory activities against the cytosolic isoforms CA I and II (offtargets) and excellent, low nanomolar inhibitory activity against the ...