Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease

C Lu, Y Guo, J Yan, Z Luo, HB Luo, M Yan…

文献索引：Lu, Chuanjun; Guo, Yueyan; Yan, Jun; Luo, Zonghua; Luo, Hai-Bin; Yan, Ming; Huang, Ling; Li, Xingshu Journal of Medicinal Chemistry, 2013 , vol. 56, # 14 p. 5843 - 5859

全文：HTML全文

被引用次数: 65

摘要

A series of multitarget-directed resveratrol derivatives was designed and synthesized for the treatment of Alzheimer's disease (AD). In vitro studies indicated that most of the target compounds exhibit significant inhibition of self-induced β-amyloid (Aβ) aggregation and Cu (II)-induced Aβ1–42 aggregation and acted as potential antioxidants and biometal chelators. In particular, compounds 5d and 10d are potential lead compounds for AD therapy (5d, ...

The design, synthesis, and anti-tumor mechanism study of N-p...

[Liu, Huachen; Dong, Aijun; Gao, Chunmei; Tan, Chunyan; Liu, Hongxia; Zu, Xuyu; Jiang, Yuyang Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10013 - 10021]

Design, synthesis, and biological evaluation of resveratrol ...

[Sun, Bin; Hoshino, Juma; Jermihov, Katie; Marler, Laura; Pezzuto, John M.; Mesecar, Andrew D.; Cushman, Mark Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 5352 - 5366]

Heterocyclic and phenyl double-bond-locked combretastatin an...

[Roberti, Marinella; Pizzirani, Daniela; Simoni, Daniele; Rondanin, Riccardo; Baruchello, Riccardo; Bonora, Caterina; Buscemi, Filippo; Grimaudo, Stefania; Tolomeo, Manlio Journal of Medicinal Chemistry, 2003 , vol. 46, # 16 p. 3546 - 3554]