The design, synthesis, and anti-tumor mechanism study of N-phosphoryl amino acid modified resveratrol analogues

…, A Dong, C Gao, C Tan, H Liu, X Zu, Y Jiang

文献索引：Liu, Huachen; Dong, Aijun; Gao, Chunmei; Tan, Chunyan; Liu, Hongxia; Zu, Xuyu; Jiang, Yuyang Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10013 - 10021

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被引用次数: 31

摘要

A novel series of trans-N-phosphoryl amino acid modified resveratrol analogues were synthesized and evaluated in vitro for their cytotoxic effects against CNE-1 and CNE-2 cell lines. These analogues showed good anti-proliferative activity, among which 8d, 8e, 8j, and 9d displayed much stronger inhibition effect than resveratrol and 8d showed the most potent activity with IC50 value at 3.45±0.82 μM. The anti-tumor effects of 8d, 8e, 8j, and 9d were ...