Multidentate 18F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA)

…, W Qu, F Hefti, M Mintun, D Skovronsky…

文献索引：Zha, Zhihao; Choi, Seok Rye; Ploessl, Karl; Lieberman, Brian P.; Qu, Wenchao; Hefti, Franz; Mintun, Mark; Skovronsky, Daniel; Kung, Hank F. Journal of Medicinal Chemistry, 2011 , vol. 54, # 23 p. 8085 - 8098

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被引用次数: 21

摘要

β-Amyloid plaques (Aβ plaques) in the brain are associated with cerebral amyloid angiopathy (CAA). Imaging agents that could target the Aβ plaques in the living human brain would be potentially valuable as biomarkers in patients with CAA. A new series of 18F styrylpyridine derivatives with high molecular weights for selectively targeting Aβ plaques in the blood vessels of the brain but excluded from the brain parenchyma is reported. The ...