Aluminum Triflate as a Powerful Catalyst for Direct Amination of Alcohols, Including Electron??Withdrawing Group??Substituted Benzhydrols

…, Y Nakahara, R Shibuya, K Mashima

文献索引：Ohshima, Takashi; Ipposhi, Junji; Nakahara, Yasuhito; Shibuya, Ryozo; Mashima, Kazushi Advanced Synthesis and Catalysis, 2012 , vol. 354, # 13 p. 2447 - 2452

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被引用次数: 20

摘要

Abstract Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron-withdrawing (F, Br, I, NO 2, or CN) substituents were efficiently catalyzed by aluminum triflate [Al (OTf) 3] to afford the corresponding biarylamines in high yield, and the dibromo-substituted product was further transformed into letrozole.