Chemical Communications

Iterative approach to polyketide-type structures: stereoselective synthesis of 1, 3-polyols utilizing the catalytic asymmetric Overman esterification

JT Binder, SF Kirsch

文献索引：Binder, Joerg T.; Kirsch, Stefan F. Chemical Communications, 2007 , # 40 p. 4164 - 4166

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被引用次数: 22

摘要

Polyketide -derived natural products often combine a specific biological activity with both complexity and broad skeletal diversity. As a synthetic challenge, they have stimulated the development of numerous methods for their stereoselective synthesis , many of which resulted in de-novo syntheses. 1,2 However, nature has evolved an iterative and flexible approach for the synthesis of polyketides utilizing only a few building blocks. 3 By mimicking this processive ...