Diastereoselective Nucleophilic Addition to Aldehydes with Polar α??and α, β??Substituents

…, J Danielsson, M Mohiti, P Restorp…

文献索引：Borg, Tessie; Danielsson, Jakob; Mohiti, Maziar; Restorp, Per; Somfai, Peter Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 2022 - 2036

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被引用次数: 9

摘要

Abstract The stereoselectivities obtained in Lewis acid-promoted Mukaiyama aldol additions and Sakurai allylations of mono-, and syn-and anti-disubstituted aldehydes possessing various polar α-and β-substituents under non-chelating conditions are presented. The stereochemical outcome in the nucleophilic addition to α-substituted aldehydes containing an α-benzyloxy, α-fluoro or α-sulfonamide substituent are accurately predicted by current ...