Tetrahedron letters

Synthetic approach to enyne and enediyne analogues of anticancer agents

O Provot, A Giraud, JF Peyrat, M Alami, JD Brion

文献索引：Provot, Olivier; Giraud, Anne; Peyrat, Jean-Francois; Alami, Mouad; Brion, Jean-Daniel Tetrahedron Letters, 2005 , vol. 46, # 49 p. 8547 - 8550

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被引用次数: 46

摘要

Combretastatin A-4 (CA-4) 1, a natural stilbene, has been extracted from the South African willow Combretum caffrum in 1987 1 and its synthesis has been published in 1995. 2 This substance, likeness to colchicine, has been found to be a cytotoxic agent which strongly inhibits the tubulin polymerization by binding to the colchicine site 2 and 3 and a pro-drug of CA-4, the water-soluble phosphate derivative CA-4P is now in phase II clinical trials. The structural ...