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Alkylation of enamines derived from sterically hindered amines

TJ Curphey, JCY Hung, CCC Chu

文献索引:Curphey,T.J. et al. Journal of Organic Chemistry, 1975 , vol. 40, p. 607 - 614

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被引用次数: 29

摘要

Alkylation by alkyl halides and oxonium salts of enamines derived from a series of sterically hindered amines was studied. Cyclohexanone enamines of diisobutylamine, n- butylisobutylamine, and 2, 2-dimethylpyrrolidine were found in some cases to give improved yields of C-alkylated products. Application to enamines of mono-and disubstituted acetaldehydes led to a useful procedure for the C-alkylation of such aldehydes by simple ...