Organophosphorus chemistry. Part 1. The synthesis of alkyl methylphosphonic acids

CM Timperley, M Bird, I Holden…

文献索引：Timperley, Christopher M.; Bird, Michael; Holden, Ian; Black, Robin M. Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 1 p. 26 - 30

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被引用次数: 25

摘要

Several alkyl hydrogen methylphosphonates of structure RO (HO) P (O) Me were synthesised by a three-stage route [R= i-Pr, n-Bu, i-Bu, s-Bu, pinacolyl Me3C-CH (Me)-, cyclopentyl and cyclohexyl]. Trimethyl phosphite was transesterified with alcohols in the presence of sodium catalyst to give the mixed phosphites (MeO) 2POR in 6–64% yield. Treatment of these with methyl iodide gave alkyl methyl methylphosphonates RO (MeO) P ...