The Journal of Organic Chemistry

Amidation of esters with amides in the presence of methoxide ion

EL Allred, MD Hurwitz

文献索引：Allred,E.L.; Hurwitz,M.D. Journal of Organic Chemistry, 1965 , vol. 30, p. 2376 - 2381

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被引用次数: 13

摘要

Methyl esters have been found to undergo amidation when treated with formamide or N- methylformamide in the presence of catalytic amounts of sodium methoxide. In addition to the new amide, other reaction products are methyl formate and methyl alcohol. Carbon monoxide is an additional product with N-methylformamide. Amidation also can be effected with esters other than methyl esters and with amides other than formamides. In this regard, ...