Organic letters

Efficient Synthesis of Dissymmetric Malonic Acid S, O-Esters via Monoalcoholysis of Symmetric Dithiomalonates under Neutral Conditions

K Matsuo, M Shindo

文献索引：Matsuo, Kazumasa; Shindo, Mitsuru Organic Letters, 2011 , vol. 13, # 16 p. 4406 - 4409

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被引用次数: 6

摘要

A novel method for the highly selective synthesis of dissymmetric S, O-malonates starting from symmetric diphenyl dithiomalonates under neutral conditions is described. The key step is the thermal formation of an acylketene, the stability of which would contribute to the selectivity. The synthetic utility of the dissymmetric S, O-malonates is also shown.