Enzyme Fingerprints of Activity, and Stereo??and Enantioselectivity from Fluorogenic and Chromogenic Substrate Arrays

…, F Badalassi, P Crotti, JL Reymond

文献索引：Wahler, Denis; Badalassi, Fabrizio; Crotti, Paolo; Reymond, Jean-Louis Chemistry - A European Journal, 2002 , vol. 8, # 14 p. 3211 - 3228

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被引用次数: 83

摘要

Abstract A series of stereochemically and structurally diverse fluorogenic and chromogenic substrates for hydrolytic enzymes has been synthesized and used to characterize enzyme activity profiles of esterases, lipases, proteases, peptidases, phosphatases, and epoxide hydrolases. The substrates used are particularly resilient to nonspecific reactions due to their mechanism of activation. The activities recorded with the individual substrates are ...