Synthesis and pharmacological properties of dantrolene and sodium dantrolene

…, RD Syubaev, SM Golovina, TI Vozyakova

文献索引：Oleinik, A. F.; Andreeva, N. I.; Syubaev, R. D.; Golovina, S. M.; Vozyakova, T. I. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 5 p. 310 - 312 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 5 p. 561 - 563

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被引用次数: 1

摘要

The mechanism for the myorelaxant action of these compounds differs considerably from that of curarelike compounds and central myorelaxants (meprobamate, etc.). The myorelaxant effect of I and II is due to depression of the contraction o~ the skeletal muscle (release of Ca 2+ ions from the sarcoplasmic retidulum); the the compounds no effect on the transmission of impulses by nerve fibers in the nerve-muscle synapses or muscle-fiber ...