Dealkylation of Phosphonate Esters with Chlorotrimethylsilane

AJ Gutierrez, EJ Prisbe, JC Rohloff

文献索引：Gutierrez; Prisbe; Rohloff Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1299 - 1302

全文：HTML全文

被引用次数: 8

摘要

Chlorotrimethylsilane completely dealkylates phosphonate esters at elevated temperature in a sealed reaction vessel. These conditions are tolerated by a variety of functional groups and lead to high conversions of dimethyl, diethyl and diisopropyl phosphonates to their corresponding phosphonic acids.