Dealkylation of Phosphonate Esters with Chlorotrimethylsilane

AJ Gutierrez, EJ Prisbe, JC Rohloff

Index: Gutierrez; Prisbe; Rohloff Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1299 - 1302

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Citation Number: 8

Abstract

Chlorotrimethylsilane completely dealkylates phosphonate esters at elevated temperature in a sealed reaction vessel. These conditions are tolerated by a variety of functional groups and lead to high conversions of dimethyl, diethyl and diisopropyl phosphonates to their corresponding phosphonic acids.