Traditional preparation of sulfonamides involves reaction of sulfonyl chlorides with amines, but the sulfonylation of weakly nucleophilic amines (eg, 4-aminoquinoline) is difficult. Transition-metal-catalyzed C−N bond-forming reactions are extensively utilized in industrial chemistry and academic laboratories. 6 Transition-metal-catalyzed N-arylation of sulfonamides offers a straightforward method for the preparation of N-arylsulfonamides. Despite significant ...
