Organic letters

Palladium-catalyzed intermolecular coupling of aryl chlorides and sulfonamides under microwave irradiation

G Burton, P Cao, G Li, R Rivero

Index: Burton, George; Cao, Ping; Li, Gang; Rivero, Ralph Organic Letters, 2003 , vol. 5, # 23 p. 4373 - 4376

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Citation Number: 119

Abstract

Traditional preparation of sulfonamides involves reaction of sulfonyl chlorides with amines, but the sulfonylation of weakly nucleophilic amines (eg, 4-aminoquinoline) is difficult. Transition-metal-catalyzed C−N bond-forming reactions are extensively utilized in industrial chemistry and academic laboratories. 6 Transition-metal-catalyzed N-arylation of sulfonamides offers a straightforward method for the preparation of N-arylsulfonamides. Despite significant ...