Palladium-catalyzed aerobic oxidative cross-coupling reactions of terminal alkynes with alkylzinc reagents

M Chen, X Zheng, W Li, J He, A Lei

文献索引：Chen, Mao; Zheng, Xiaolong; Li, Wenqing; He, Jun; Lei, Aiwen Journal of the American Chemical Society, 2010 , vol. 132, # 12 p. 4101 - 4103

全文：HTML全文

被引用次数: 80

摘要

With air as the oxidant, terminal alkynes can be directly cross-coupled with alkylzinc reagents in the presence of a Pd catalyst at room temperature. CO was found to be critical in gaining high chemical yields and selectivities. A wide range of alkynes and alkylzinc reagents were tested, and good to excellent yields were obtained.