Tetrahedron letters

A simple method for the direct bis-acylation of the primary amino groups in spermidine and other linear triamines

AV Joshua, JR Scott

文献索引：Joshua, Alummoottil V.; Scott, John R. Tetrahedron Letters, 1984 , vol. 25, # 50 p. 5725 - 5728

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被引用次数: 40

摘要

Abstract A simple and efficient method for the direct symmetrical bis-acylation of spermidine and other linear triamines using acylimidazoles is described. By this procedure, the siderophore natural product N 1, N 8-bis (2, 3-dihydroxybenzoyl) spermidine was synthesized in an overall yield of 70% in two steps.