Combined epimerisation and acylation: Meerwein–Ponndorf–Verley–Oppenauer catalysts in action

…, NC Svennum, N Chantapariyavat, CS Wong…

文献索引：Klomp, Dirk; Djanashvili, Kristina; Svennum, Nina Cianfanelli; Chantapariyavat, Nuttanun; Wong, Chung-Sing; Vilela, Filipe; Maschmeyer, Thomas; Peters, Joop A.; Hanefeld, Ulf Organic and Biomolecular Chemistry, 2005 , vol. 3, # 3 p. 483 - 489

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被引用次数: 29

摘要

A practical racemisation–epimerisation method for chiral secondary alcohols has been developed. Meerwein–Ponndorf–Verley-Oppenauer catalysts such as neodymium (III) isopropoxide are able to racemise these alcohols with retention of other stereocentres in the molecule. This is particularly useful for the recycling of the undesired products of kinetic resolutions of alcohols. By combination of such a racemisation with an acylation using ...