Organic letters

Practical Heck− Mizoroki Coupling Protocol for Challenging Substrates Mediated by an N-Heterocyclic Carbene-Ligated Palladacycle

EAB Kantchev, GR Peh, C Zhang, JY Ying

文献索引：Kantchev, Eric Assen B.; Peh, Guang-Rong; Zhang, Chi; Ying, Jackie Y. Organic Letters, 2008 , vol. 10, # 18 p. 3949 - 3952

全文：HTML全文

被引用次数: 62

摘要

ABSTRACT A highly active, N-heterocyclic carbene-palladacycle precatalyst for the Heck- Mizoroki reaction was rationally designed. The complex can be synthesized on a large scale in excellent yield by a novel, one-pot, three-component reaction and is tolerant to air, moisture, and long-term storage. A wide range of challenging substrates is successfully coupled under a simple and user-friendly reaction protocol.