Synthesis and cancer antiproliferative activity of new histone deacetylase inhibitors: hydrophilic hydroxamates and 2-aminobenzamide-containing derivatives

…, D Nakashima, T Oikawa, K Shimoke, T Ikeuchi…

文献索引：Nagaoka; Maeda; Kawai; Nakashima; Oikawa; Shimoke; Ikeuchi; Kuwajima; Uesato European Journal of Medicinal Chemistry, 2006 , vol. 41, # 6 p. 697 - 708

全文：HTML全文

被引用次数: 31

摘要

New series histone deacetylase inhibitors comprising a hydroxamic acid or 2- aminobenzamide group as a zinc-chelating function were synthesized and evaluated for antiproliferative activities against a panel of human cancer cells. The 2-aminobenzamide series inhibitors generally had the potency in cell growth inhibitions comparable to that of MS-275. Among them, the compound having a (3, 4-difluorobenzyl)(2-hydroxyethyl) ...