Synthesis and cancer antiproliferative activity of new histone deacetylase inhibitors: hydrophilic hydroxamates and 2-aminobenzamide-containing derivatives

…, D Nakashima, T Oikawa, K Shimoke, T Ikeuchi…

Index: Nagaoka; Maeda; Kawai; Nakashima; Oikawa; Shimoke; Ikeuchi; Kuwajima; Uesato European Journal of Medicinal Chemistry, 2006 , vol. 41, # 6 p. 697 - 708

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Citation Number: 31

Abstract

New series histone deacetylase inhibitors comprising a hydroxamic acid or 2- aminobenzamide group as a zinc-chelating function were synthesized and evaluated for antiproliferative activities against a panel of human cancer cells. The 2-aminobenzamide series inhibitors generally had the potency in cell growth inhibitions comparable to that of MS-275. Among them, the compound having a (3, 4-difluorobenzyl)(2-hydroxyethyl) ...