Tetrahedron letters

Silver catalyzed zinc Barbier reaction of benzylic halides in water

LW Bieber, EC Storch, I Malvestiti, MF da Silva

文献索引：Bieber, Lothar W.; Storch, Elisabeth C.; Malvestiti, Ivani; Da Silva, Margarete F. Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9393 - 9396

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被引用次数: 43

摘要

Benzylic chlorides react in aqueous dibasic potassium phosphate under silver catalysis with aromatic aldehydes in the presence of zinc dust to give 1, 2-diaryl alcohols in moderate to good yields. Dimerization to bibenzyls and reduction of the halide are important side reactions. A wide range of substituted aromatic and heteroaromatic aldehydes and of substituted benzylic chlorides can be used. Aliphatic aldehydes and ketones are ...