前往化源商城

举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

2, 4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 11. Quinolylmethyl analogs with basic substituents conveying specificity

SE Davis, BS Rauckman, JH Chan…

文献索引：Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1936 - 1942

全文：HTML全文

被引用次数: 18

摘要

A series of nine 2, 4-diamino-5-[6-(or 7-) quinolylmethyl] pyrimidines has been prepared by condensations of qui-nolinecarboxaldehydes with 0-anilinopropionitriles, followed by treatment with guanidine. All compounds had basic or methoxy substituents at the 2-or 4- positions of the quinoline ring. All of the 6-quinolylmethyl derivatives were highly inhibitory against Escherichia coli dihydrofolate reductase (DHFR), provided that an &substituent ...

6-bromo-8-methoxy-2-methyl-4-quinolone结构式

6-bromo-8-metho...

~94%

6-bromo-4-chloro-8-methoxy-2-methylquinoline结构式

6-bromo-4-chlor...

4-溴-2-甲氧基苯胺结构式

4-溴-2-甲氧基苯胺

~%

6-bromo-4-chloro-8-methoxy-2-methylquinoline结构式

6-bromo-4-chlor...

邻氨基苯甲醚结构式

邻氨基苯甲醚

~%

6-bromo-4-chloro-8-methoxy-2-methylquinoline结构式

6-bromo-4-chlor...

ethyl 3-(4-bromo-2-methoxyphenyl)iminobutanoate结构式

ethyl 3-(4-brom...

~%

6-bromo-4-chloro-8-methoxy-2-methylquinoline结构式

6-bromo-4-chlor...

甲醇钠结构式

6-bromo-4-chloro-8-methoxy-2-methylquinoline结构式

6-bromo-4-chlor...

~87%

6-bromo-4,8-dimethoxy-2-methylquinoline结构式

6-bromo-4,8-dim...

4-溴-2-甲氧基苯胺结构式

4-溴-2-甲氧基苯胺

~%

6-bromo-4,8-dimethoxy-2-methylquinoline结构式

6-bromo-4,8-dim...

邻氨基苯甲醚结构式

邻氨基苯甲醚

~%

6-bromo-4,8-dimethoxy-2-methylquinoline结构式

6-bromo-4,8-dim...

6-bromo-8-methoxy-2-methyl-4-quinolone结构式

6-bromo-8-metho...

~%

6-bromo-4,8-dimethoxy-2-methylquinoline结构式

6-bromo-4,8-dim...

ethyl 3-(4-bromo-2-methoxyphenyl)iminobutanoate结构式

ethyl 3-(4-brom...

~%

6-bromo-4,8-dimethoxy-2-methylquinoline结构式

6-bromo-4,8-dim...

4-溴-2-甲氧基苯胺结构式

4-溴-2-甲氧基苯胺

~%

4,8-dimethoxy-2-methylquinoline-6-carbaldehyde结构式

4,8-dimethoxy-2...

邻氨基苯甲醚结构式

邻氨基苯甲醚

~%

4,8-dimethoxy-2-methylquinoline-6-carbaldehyde结构式

4,8-dimethoxy-2...

6-bromo-8-methoxy-2-methyl-4-quinolone结构式

6-bromo-8-metho...

~%

4,8-dimethoxy-2-methylquinoline-6-carbaldehyde结构式

4,8-dimethoxy-2...

ethyl 3-(4-bromo-2-methoxyphenyl)iminobutanoate结构式

ethyl 3-(4-brom...

~%

4,8-dimethoxy-2-methylquinoline-6-carbaldehyde结构式

4,8-dimethoxy-2...

N,N-二甲基甲酰胺结构式

N,N-二甲基甲酰胺

6-bromo-4,8-dimethoxy-2-methylquinoline结构式

6-bromo-4,8-dim...

~%

4,8-dimethoxy-2-methylquinoline-6-carbaldehyde结构式

4,8-dimethoxy-2...

6-formyl-4,8-dimethoxy-2-(n-pentyl)quinoline结构式

6-formyl-4,8-di...

正丁基锂结构式

N,N-二甲基甲酰胺结构式

N,N-二甲基甲酰胺

6-bromo-4,8-dimethoxy-2-methylquinoline结构式

6-bromo-4,8-dim...

~%

4,8-dimethoxy-2-methylquinoline-6-carbaldehyde结构式

4,8-dimethoxy-2...

详细

N-(4-bromo-2-methylphenyl)-3-oxobutanamide结构式

N-(4-bromo-2-me...

~62%

6-bromo-4,8-dimethyl-1H-quinolin-2-one结构式

6-bromo-4,8-dim...

4-溴-2-甲基苯胺结构式

4-溴-2-甲基苯胺

~%

6-bromo-4,8-dimethyl-1H-quinolin-2-one结构式

6-bromo-4,8-dim...

6-bromo-4-chloro-8-methoxy-2-methylquinoline结构式

6-bromo-4-chlor...

~%

4,8-dimethoxy-2-methylquinoline-6-carbaldehyde结构式

4,8-dimethoxy-2...

4-溴-2-甲氧基苯胺结构式

4-溴-2-甲氧基苯胺

~%

5-[(4,8-dimethoxy-2-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4,8-dimetho...

邻氨基苯甲醚结构式

邻氨基苯甲醚

~%

5-[(4,8-dimethoxy-2-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4,8-dimetho...

6-bromo-4-chloro-8-methoxy-2-methylquinoline结构式

6-bromo-4-chlor...

~%

5-[(4,8-dimethoxy-2-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4,8-dimetho...

6-bromo-8-methoxy-2-methyl-4-quinolone结构式

6-bromo-8-metho...

~%

5-[(4,8-dimethoxy-2-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4,8-dimetho...

ethyl 3-(4-bromo-2-methoxyphenyl)iminobutanoate结构式

ethyl 3-(4-brom...

~%

5-[(4,8-dimethoxy-2-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4,8-dimetho...

6-bromo-4,8-dimethoxy-2-methylquinoline结构式

6-bromo-4,8-dim...

~%

5-[(4,8-dimethoxy-2-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4,8-dimetho...

4,8-dimethoxy-2-methylquinoline-6-carbaldehyde结构式

4,8-dimethoxy-2...

~%

5-[(4,8-dimethoxy-2-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(4,8-dimetho...

二甲胺结构式

6-bromo-4-chloro-8-methoxy-2-methylquinoline结构式

6-bromo-4-chlor...

~87%

6-bromo-8-methoxy-N,N,2-trimethylquinolin-4-amine结构式

6-bromo-8-metho...

4-溴-2-甲氧基苯胺结构式

4-溴-2-甲氧基苯胺

~%

6-bromo-8-methoxy-N,N,2-trimethylquinolin-4-amine结构式

6-bromo-8-metho...

邻氨基苯甲醚结构式

邻氨基苯甲醚

~%

6-bromo-8-methoxy-N,N,2-trimethylquinolin-4-amine结构式

6-bromo-8-metho...

6-bromo-8-methoxy-2-methyl-4-quinolone结构式

6-bromo-8-metho...

~%

6-bromo-8-methoxy-N,N,2-trimethylquinolin-4-amine结构式

6-bromo-8-metho...

ethyl 3-(4-bromo-2-methoxyphenyl)iminobutanoate结构式

ethyl 3-(4-brom...

~%

6-bromo-8-methoxy-N,N,2-trimethylquinolin-4-amine结构式

6-bromo-8-metho...

6-bromo-4,8-dimethyl-1H-quinolin-2-one结构式

6-bromo-4,8-dim...

~99%

6-bromo-2-chloro-4,8-dimethylquinoline结构式

6-bromo-2-chlor...

4-溴-2-甲基苯胺结构式

4-溴-2-甲基苯胺

~%

6-bromo-2-chloro-4,8-dimethylquinoline结构式

6-bromo-2-chlor...

N-(4-bromo-2-methylphenyl)-3-oxobutanamide结构式

N-(4-bromo-2-me...

~%

6-bromo-2-chloro-4,8-dimethylquinoline结构式

6-bromo-2-chlor...

4-溴-2-甲基苯胺结构式

4-溴-2-甲基苯胺

~%

4-(6-bromo-4,8-dimethylquinolin-2-yl)morpholine结构式

4-(6-bromo-4,8-...

吗啉结构式

6-bromo-2-chloro-4,8-dimethylquinoline结构式

6-bromo-2-chlor...

~96%

4-(6-bromo-4,8-dimethylquinolin-2-yl)morpholine结构式

4-(6-bromo-4,8-...

6-bromo-4,8-dimethyl-1H-quinolin-2-one结构式

6-bromo-4,8-dim...

~%

4-(6-bromo-4,8-dimethylquinolin-2-yl)morpholine结构式

4-(6-bromo-4,8-...

N-(4-bromo-2-methylphenyl)-3-oxobutanamide结构式

N-(4-bromo-2-me...

~%

4-(6-bromo-4,8-dimethylquinolin-2-yl)morpholine结构式

4-(6-bromo-4,8-...

4-溴-2-甲氧基苯胺结构式

4-溴-2-甲氧基苯胺

~%

4-(dimethylamino)-8-methoxy-2-methylquinoline-6-carbaldehyde结构式

4-(dimethylamin...

邻氨基苯甲醚结构式

邻氨基苯甲醚

~%

4-(dimethylamino)-8-methoxy-2-methylquinoline-6-carbaldehyde结构式

4-(dimethylamin...

6-bromo-4-chloro-8-methoxy-2-methylquinoline结构式

6-bromo-4-chlor...

~%

4-(dimethylamino)-8-methoxy-2-methylquinoline-6-carbaldehyde结构式

4-(dimethylamin...

6-bromo-8-methoxy-2-methyl-4-quinolone结构式

6-bromo-8-metho...

~%

4-(dimethylamino)-8-methoxy-2-methylquinoline-6-carbaldehyde结构式

4-(dimethylamin...

ethyl 3-(4-bromo-2-methoxyphenyl)iminobutanoate结构式

ethyl 3-(4-brom...

~%

4-(dimethylamino)-8-methoxy-2-methylquinoline-6-carbaldehyde结构式

4-(dimethylamin...

N,N-二甲基甲酰胺结构式

N,N-二甲基甲酰胺

6-bromo-8-methoxy-N,N,2-trimethylquinolin-4-amine结构式

6-bromo-8-metho...

~%

4-(dimethylamino)-8-methoxy-2-methylquinoline-6-carbaldehyde结构式

4-(dimethylamin...

4-(dimethylamino)-8-methoxy-2-pentylquinoline-6-carbaldehyde结构式

4-(dimethylamin...

正丁基锂结构式

N,N-二甲基甲酰胺结构式

N,N-二甲基甲酰胺

6-bromo-8-methoxy-N,N,2-trimethylquinolin-4-amine结构式

6-bromo-8-metho...

~%

4-(dimethylamino)-8-methoxy-2-methylquinoline-6-carbaldehyde结构式

4-(dimethylamin...

详细

6-溴-2-氯-4-甲基喹啉结构式

6-溴-2-氯-4-甲基喹啉

二甲胺结构式

~71%

6-bromo-N,N,4-trimethylquinolin-2-amine结构式

6-bromo-N,N,4-t...

N-(4-溴苯基)-3-氧代丁酰胺结构式

N-(4-溴苯基)-3-氧代丁酰胺

~%

6-bromo-N,N,4-trimethylquinolin-2-amine结构式

6-bromo-N,N,4-t...

6-溴-4-甲基-2(1H)-喹啉酮结构式

6-溴-4-甲基-2(1H)-喹啉酮

~%

6-bromo-N,N,4-trimethylquinolin-2-amine结构式

6-bromo-N,N,4-t...

6-溴-2-氯-4-甲基喹啉结构式

6-溴-2-氯-4-甲基喹啉

~%

2-(dimethylamino)-4-methylquinoline-6-carbaldehyde结构式

2-(dimethylamin...

N-(4-溴苯基)-3-氧代丁酰胺结构式

N-(4-溴苯基)-3-氧代丁酰胺

~%

2-(dimethylamino)-4-methylquinoline-6-carbaldehyde结构式

2-(dimethylamin...

6-溴-4-甲基-2(1H)-喹啉酮结构式

6-溴-4-甲基-2(1H)-喹啉酮

~%

2-(dimethylamino)-4-methylquinoline-6-carbaldehyde结构式

2-(dimethylamin...

N,N-二甲基甲酰胺结构式

N,N-二甲基甲酰胺

6-bromo-N,N,4-trimethylquinolin-2-amine结构式

6-bromo-N,N,4-t...

~%

2-(dimethylamino)-4-methylquinoline-6-carbaldehyde结构式

2-(dimethylamin...

4-溴-2-甲基苯胺结构式

4-溴-2-甲基苯胺

~%

4,8-dimethyl-2-morpholin-4-ylquinoline-6-carbaldehyde结构式

4,8-dimethyl-2-...

6-bromo-2-chloro-4,8-dimethylquinoline结构式

6-bromo-2-chlor...

~%

4,8-dimethyl-2-morpholin-4-ylquinoline-6-carbaldehyde结构式

4,8-dimethyl-2-...

6-bromo-4,8-dimethyl-1H-quinolin-2-one结构式

6-bromo-4,8-dim...

~%

4,8-dimethyl-2-morpholin-4-ylquinoline-6-carbaldehyde结构式

4,8-dimethyl-2-...

N-(4-bromo-2-methylphenyl)-3-oxobutanamide结构式

N-(4-bromo-2-me...

~%

4,8-dimethyl-2-morpholin-4-ylquinoline-6-carbaldehyde结构式

4,8-dimethyl-2-...

N,N-二甲基甲酰胺结构式

N,N-二甲基甲酰胺

4-(6-bromo-4,8-dimethylquinolin-2-yl)morpholine结构式

4-(6-bromo-4,8-...

~%

4,8-dimethyl-2-morpholin-4-ylquinoline-6-carbaldehyde结构式

4,8-dimethyl-2-...

6-溴-4-甲基-2(1H)-喹啉酮结构式

6-溴-4-甲基-2(1H)-喹啉酮

~95%

6-溴-2-氯-4-甲基喹啉结构式

6-溴-2-氯-4-甲基喹啉

N-(3-bromophenyl)-3-oxo-butanamide结构式

N-(3-bromopheny...

~%

7-Bromo-2-chloro-4-methyl-1-azanaphthalene结构式

7-Bromo-2-chlor...

甲醇钠结构式

7-Bromo-2-chloro-4-methyl-1-azanaphthalene结构式

7-Bromo-2-chlor...

~85%

7-bromo-2-methoxy-4-methylquinoline结构式

7-bromo-2-metho...

N-(3-bromophenyl)-3-oxo-butanamide结构式

N-(3-bromopheny...

~%

7-bromo-2-methoxy-4-methylquinoline结构式

7-bromo-2-metho...

7-bromo-4-methyl-1H-quinolin-2-one结构式

7-bromo-4-methy...

~%

7-bromo-2-methoxy-4-methylquinoline结构式

7-bromo-2-metho...

4-溴-2-甲氧基苯胺结构式

4-溴-2-甲氧基苯胺

乙酰乙酸乙酯结构式

乙酰乙酸乙酯

~79%

ethyl 3-(4-bromo-2-methoxyphenyl)iminobutanoate结构式

ethyl 3-(4-brom...

邻氨基苯甲醚结构式

邻氨基苯甲醚

~%

ethyl 3-(4-bromo-2-methoxyphenyl)iminobutanoate结构式

ethyl 3-(4-brom...

N,N-二甲基甲酰胺结构式

N,N-二甲基甲酰胺

7-bromo-2-methoxy-4-methylquinoline结构式

7-bromo-2-metho...

~%

2-methoxy-4-methylquinoline-7-carbaldehyde结构式

2-methoxy-4-met...

N-(3-bromophenyl)-3-oxo-butanamide结构式

N-(3-bromopheny...

~%

2-methoxy-4-methylquinoline-7-carbaldehyde结构式

2-methoxy-4-met...

7-bromo-4-methyl-1H-quinolin-2-one结构式

7-bromo-4-methy...

~%

2-methoxy-4-methylquinoline-7-carbaldehyde结构式

2-methoxy-4-met...

7-Bromo-2-chloro-4-methyl-1-azanaphthalene结构式

7-Bromo-2-chlor...

~%

2-methoxy-4-methylquinoline-7-carbaldehyde结构式

2-methoxy-4-met...

盐酸胍结构式

未登录结构式

~13%

5-[(2-methoxy-4-methylquinolin-7-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(2-methoxy-4...

N-(3-bromophenyl)-3-oxo-butanamide结构式

N-(3-bromopheny...

~%

5-[(2-methoxy-4-methylquinolin-7-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(2-methoxy-4...

7-bromo-4-methyl-1H-quinolin-2-one结构式

7-bromo-4-methy...

~%

5-[(2-methoxy-4-methylquinolin-7-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(2-methoxy-4...

7-Bromo-2-chloro-4-methyl-1-azanaphthalene结构式

7-Bromo-2-chlor...

~%

5-[(2-methoxy-4-methylquinolin-7-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(2-methoxy-4...

7-bromo-2-methoxy-4-methylquinoline结构式

7-bromo-2-metho...

~%

5-[(2-methoxy-4-methylquinolin-7-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(2-methoxy-4...

2-methoxy-4-methylquinoline-7-carbaldehyde结构式

2-methoxy-4-met...

~%

5-[(2-methoxy-4-methylquinolin-7-yl)methyl]pyrimidine-2,4-diamine结构式

5-[(2-methoxy-4...

双乙烯酮结构式

4-溴-2-甲基苯胺结构式

4-溴-2-甲基苯胺

~54%

N-(4-bromo-2-methylphenyl)-3-oxobutanamide结构式

N-(4-bromo-2-me...