5-(1-Piperazinyl)-1H-1, 2, 4-triazol-3-amines as antihypertensive agents

WE Meyer, AS Tomcufcik, PS Chan…

文献索引：Meyer; Tomcufcik; Chan; Haug Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 593 - 597

全文：HTML全文

被引用次数: 18

摘要

Discussion Blood pressure lowering and diuretic activity was assessed in spontaneously hypertensive rats (SHR). As may be seen from Table I, a number of"-benzyl-and N'-alkyl- substituted piperazines show blood pressure lowering properties. Alkyl (36, 371, phenylalkyl (5, 6, 7, 42), and phenoxyalkyl (44) derivatives, with the exception of those alkyl groups containing nitrogen (41, 43), lower blood pressure as much as 75 mmHg below control ...