5-(1-Piperazinyl)-1H-1, 2, 4-triazol-3-amines as antihypertensive agents

WE Meyer, AS Tomcufcik, PS Chan…

Index: Meyer; Tomcufcik; Chan; Haug Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 593 - 597

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Citation Number: 18

Abstract

Discussion Blood pressure lowering and diuretic activity was assessed in spontaneously hypertensive rats (SHR). As may be seen from Table I, a number of"-benzyl-and N'-alkyl- substituted piperazines show blood pressure lowering properties. Alkyl (36, 371, phenylalkyl (5, 6, 7, 42), and phenoxyalkyl (44) derivatives, with the exception of those alkyl groups containing nitrogen (41, 43), lower blood pressure as much as 75 mmHg below control ...