Synthesis and antimonoamine oxidase activity of 8-(N-methyl-N-2-propynyl) aminomethylquinolines

…, IR Kovel'man, AI Tochilkin, IV Verevkina…

文献索引：Gracheva, I. N.; Kovel'man, I. R.; Tochilkin, A. I.; Verevkina, I. V.; Ioffina, D. I.; Gorkin, V. Z. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 625 - 629 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1055 - 1060

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摘要

The most powerful and specific inhibitors of mitochondrial monoamine oxidase (MAO) yet known are 2-propynylamine derivatives [i]. Searches have been carried out [2-4] for even more powerful and selective MAO inhibitors in the deprenil and pargiiin groups, and the relationships between structure and antimonoamine oxidase activity have been examined.