Metal-and Oxidant-Free Synthesis of Quinazolinones from β-Ketoesters with o-Aminobenzamides via Phosphorous Acid-Catalyzed Cyclocondensation and Selective …
A general and efficient phosphorous acid-catalyzed cyclocondensation of β-ketoesters with o-aminobenzamides via selective C–C bond cleavage leading to quinazolinones is developed. This reaction proceeds smoothly under metal-and oxidant-free conditions, giving