Synthesis, acute toxicities, and antitumor effects of novel 9-substituted β-carboline derivatives

R Cao, Q Chen, X Hou, H Chen, H Guan, Y Ma…

文献索引：Cao, Rihui; Chen, Qi; Hou, Xuerui; Chen, Hongsheng; Guan, Huaji; Ma, Yan; Peng, Wenlie; Xu, Anlong Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4613 - 4623

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被引用次数: 120

摘要

A series of novel 9-substituted β-carboline derivatives was synthesized from harmine and l- tryptophan, respectively. Cytotoxic activities of these compounds in vitro were investigated. The results showed that most compounds of 9-substituted β-carboline derivatives had more remarkable cytotoxic activities in vitro than their corresponding parent compounds. Acute toxicities and antitumor effects of the selected β-carboline derivatives in mice were also ...