Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs

R Pereira, C Gaudon, B Iglesias, P Germain…

文献索引：Pereira, Raquel; Gaudon, Claudine; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; De Lera, Angel R. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 49 - 54

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被引用次数: 55

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole provided the scaffold for the synthesis of GW501516, the most potent PPARβ/δ agonist yet described, and equally selective analogs at the thiazole-C4 position.