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4-Sulphamoylphenyl semicarbazones with anticonvulsant activity

P Yogeeswari, D Sriram, SN Pandeya, JP Stables

文献索引：Yogeeswari; Sriram; N.pandeya; Stables Farmaco, 2004 , vol. 59, # 8 p. 609 - 613

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被引用次数: 42

摘要

A series of 4-sulphamoylphenyl semicarbazone derivatives were prepared starting from sulphanilamide and screened for anticonvulsant activity. The results indicated that greater protection was obtained in the maximal electroshock screen (MES) and subcutaneous strychnine (scSTY) than the subcutaneous pentylenetetrazole (scPTZ) tests. All the compounds showed low neurotoxicity when compared to the clinically used drugs. ...