Abstract: The importance of the@-hydroxy ketone moiety has led to the development of a wide variety of aldol type methodologies for its construction. A conceptually new approach to these" aldol adducts" is presented on the basis of [3+ 21 dipolar cycloaddition of in situ generated nitrile oxides and olefins followed by reduction of the resulting A2-isoxazolines. This approach provides a nice complement to the aldol type reaction. Optimum conditions ...
