Tetrahedron: Asymmetry

Lipase-catalyzed resolution of esters of 4-chloro-3-hydroxybutanoic acid: effects of the alkoxy group and solvent on the enantiomeric ratio

BH Hoff, T Anthonsen

文献索引：Hoff, Bard Helge; Anthonsen, Thorleif Tetrahedron Asymmetry, 1999 , vol. 10, # 7 p. 1401 - 1412

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被引用次数: 34

摘要

Various lipases have been investigated for their potential use as catalysts for the resolution of esters of 4-chloro-3-hydroxybutanoic acid via transesterification in organic solvents. Rhizomucor miehei lipase was found to be the most efficient lipase, with the enantiomeric ratio (E) being dependent upon of the nature of the alkoxy group of the ester and the resolution medium. Higher E-values were obtained when transesterification was ...