Tetrahedron: Asymmetry

Lipase-catalyzed resolution of esters of 4-chloro-3-hydroxybutanoic acid: effects of the alkoxy group and solvent on the enantiomeric ratio

BH Hoff, T Anthonsen

Index: Hoff, Bard Helge; Anthonsen, Thorleif Tetrahedron Asymmetry, 1999 , vol. 10, # 7 p. 1401 - 1412

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Citation Number: 34

Abstract

Various lipases have been investigated for their potential use as catalysts for the resolution of esters of 4-chloro-3-hydroxybutanoic acid via transesterification in organic solvents. Rhizomucor miehei lipase was found to be the most efficient lipase, with the enantiomeric ratio (E) being dependent upon of the nature of the alkoxy group of the ester and the resolution medium. Higher E-values were obtained when transesterification was ...