Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 3. Replacement of quinazoline moiety and improvement of metabolic …

K Matsuno, J Ushiki, T Seishi, M Ichimura…

文献索引：Matsuno, Kenji; Ushiki, Junko; Seishi, Takashi; Ichimura, Michio; Giese, Neill A.; Yu, Jin-Chen; Takahashi, Shusuke; Oda, Shoji; Nomoto, Yuji Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 4910 - 4925

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被引用次数: 43

摘要

We have previously reported that a series of 4-[4-(N-substituted (thio) carbamoyl)-1- piperazinyl]-6, 7-dimethoxyquinazoline derivatives were potent and selective inhibitors of platelet-derived growth factor receptor (PDGFR) phosphorylation and demonstrated several biological effects such as suppression of neointima formation following balloon injury in rat carotid artery by oral administration. Here, we investigated structure-activity relationships ...