Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 3. Replacement of quinazoline moiety and improvement of metabolic …

K Matsuno, J Ushiki, T Seishi, M Ichimura…

Index: Matsuno, Kenji; Ushiki, Junko; Seishi, Takashi; Ichimura, Michio; Giese, Neill A.; Yu, Jin-Chen; Takahashi, Shusuke; Oda, Shoji; Nomoto, Yuji Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 4910 - 4925

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Citation Number: 43

Abstract

We have previously reported that a series of 4-[4-(N-substituted (thio) carbamoyl)-1- piperazinyl]-6, 7-dimethoxyquinazoline derivatives were potent and selective inhibitors of platelet-derived growth factor receptor (PDGFR) phosphorylation and demonstrated several biological effects such as suppression of neointima formation following balloon injury in rat carotid artery by oral administration. Here, we investigated structure-activity relationships ...