Synthesis

Selective access to secondary amines by a highly controlled reductive mono-n-alkylation of primary amines

…, S Bhattacharyya, EW Rehr, AM Gonzalez

文献索引：Kumpaty, Hephzibah J.; Bhattacharyya, Sukanta; Rehr, Erik W.; Gonzalez, Amelia M. Synthesis, 2003 , # 14 p. 2206 - 2210

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被引用次数: 18

摘要

Abstract A selective and direct access to secondary amines is reported by reductive mono-N- alkylation of primary amines in the presence of Ti (i-PrO) 4 and NaBH 4. Secondary amines are obtained exclusively from a set of carbonyl compounds and primary amines, demonstrating high chemoselectivity toward reductive mono-N-alkylation.