Abstract A series of 8-hydroxy-1, 6-naphthyridin-5 (6H)-one-7-carboxamides 1 and the isomeric 5-hydroxy-1, 7-naphthyridin-8 (7H)-one-6-carboxamides 2 were synthesized. N- Lactam unsubstituted compounds 1a-c and 2a, b were obtained by alkoxide-induced rearrangement of the corresponding quinolinimidoacetamides 3. Compounds 1e, f and 2e, f were synthesized by heterocyclization of the corresponding quinolinamic esters 6 and 7. ...
[Ornstein, Paul L.; Schaus, John M.; Chambers, John W.; Huser, Diane L.; Leander, J. David; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 827 - 833]
