The Journal of Organic Chemistry

Folate analogs. 24. Syntheses of the antitumor agents 10-deazaaminopterin (10-DAAM) and 10-ethyl-10-deazaaminopterin (10-EDAAM)

MG Nair

文献索引：Nair, M. G. Journal of Organic Chemistry, 1985 , vol. 50, # 11 p. 1879 - 1884

被引用次数: 12

摘要

Methods have been developed for the chemical synthesis of two recently described potent antitumor agents. They are 10-deazaaminopterin (10-DUM)(2) and 10-ethyl-10- deazaaminopterin(10-EDAAM)(3). The methods described in this paper have general applicability for the synthesis of a variety of hitherto difficultly accessible 10-substituted-10- dedolic acids and analogues. Reaction of methyl p-formylbenzoate (7) with the Wittig ...

Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5, ...

[Piper; Johnson; Otter; Sirotnak Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3002 - 3006]

Synthesis and antitumor activity of 10-alkyl-10-deazaminopte...

[DeGraw; Brown; Tagawa; Kisliuk; Gaumont; Sirotnak Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1227 - 1230]